This randomized phase III trial studies how well doxorubicin hydrochloride and cyclophosphamide followed by paclitaxel with or without carboplatin work in treating patients with triple-negative breast cancer. Drugs used in chemotherapy, such as doxorubicin hydrochloride, cyclophosphamide, paclitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether doxorubicin hydrochloride and cyclophosphamide is more effective when followed by paclitaxel alone or paclitaxel and carboplatin in treating triple-negative breast cancer.
Lead Organization
NRG Oncology
Principal Investigator
Vicente Valero
这个随机III期试验研究盐酸阿霉素和环磷酰胺以及紫杉醇联合或不联合卡铂治疗三阴性乳腺癌的效果如何。用于化疗的药物,如盐酸阿霉素、环磷酰胺、紫杉醇和卡铂,通过杀死细胞、阻止细胞分裂或阻止肿瘤细胞扩散,以不同的方式阻止肿瘤细胞生长。目前尚不清楚盐酸阿霉素和环磷酰胺是单用紫杉醇还是单用紫杉醇和卡铂治疗三阴性乳腺癌更有效。