最新临床试验：持续化疗是否合并局部巩固治疗对IV期非小细胞肺癌的疗效

这是经美国国家癌症研究所批准的一项多中心随机对照II / III期临床试验，目的是研究局部巩固治疗或不局部巩固治疗对IV期非小细胞肺癌患者持续化疗的影响。用于维持化疗的药物，如多西他赛、培美曲塞二钠、盐酸埃洛替尼和吉西他滨以不同的方式阻止肿瘤细胞的生长，或杀死肿瘤细胞，或阻止肿瘤细胞分裂，或阻止肿瘤细胞扩散。局部巩固治疗，如放射/立体定向身体辐射或手术，可能会杀死初步治疗后留下的癌细胞。持续化疗合并局部巩固治疗对四期非小细胞肺癌患者可能比单独维持化疗的效果更好。

该临床试验正在全美191家医院进行开展。

This randomized phase II / III trial studies how well giving maintenance chemotherapy with or without local consolidation therapy works in treating patients with stage IV non-small cell lung cancer. Drugs used in maintenance chemotherapy, such as docetaxel, pemetrexed disodium, erlotinib hydrochloride, and gemcitabine work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Local consolidation therapy such as radiation / stereotactic body radiation or surgery may kill cancer cells left after initial treatment. Giving maintenance chemotherapy and local consolidation therapy together may work better than maintenance chemotherapy alone in treating patients with stage IV non-small cell lung cancer.

Trial IDs